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TitleInhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis.
Journal, issue, pagesBiochemistry, Vol. 32, Page 7972-7980, Year 1993
Publish dateApr 6, 1993 (structure data deposition date)
AuthorsAbdel-Meguid, S.S. / Zhao, B. / Murthy, K.H. / Winborne, E. / Choi, J.K. / DesJarlais, R.L. / Minnich, M.D. / Culp, J.S. / Debouck, C. / Tomaszek Jr., T.A. ...Abdel-Meguid, S.S. / Zhao, B. / Murthy, K.H. / Winborne, E. / Choi, J.K. / DesJarlais, R.L. / Minnich, M.D. / Culp, J.S. / Debouck, C. / Tomaszek Jr., T.A. / Meek, T.D. / Dreyer, G.B.
External linksBiochemistry / PubMed:8347601
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-1hos:
INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-PHP:
(2-PHENYL-1-CARBOBENZYL-OXYVALYL-AMINO)-ETHYL-PHOSPHINIC ACID

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE(ACID PROTEINASE)

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