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Structure paper

TitleThree-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors.
Journal, issue, pagesBiochemistry, Vol. 32, Page 13054-13060, Year 1993
Publish dateAug 24, 1993 (structure data deposition date)
AuthorsZhao, B. / Winborne, E. / Minnich, M.D. / Culp, J.S. / Debouck, C. / Abdel-Meguid, S.S.
External linksBiochemistry / PubMed:8241159
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-1siv:
THREE-DIMENSIONAL STRUCTURE OF A SIV PROTEASE(SLASH)INHIBITOR COMPLEX. IMPLICATIONS FOR THE DESIGN OF HIV-1 AND HIV-2 PROTEASE INHIBITORS
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-PSI:
methyl N-{(4S,5S)-5-[(L-alanyl-L-alanyl)amino]-4-hydroxy-6-phenylhexanoyl}-L-valyl-L-valinate

ChemComp-HOH:
WATER

Source
  • simian immunodeficiency virus
KeywordsHYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / ACID PROTEINASE

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