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TitleTyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.
Journal, issue, pagesBiochemistry, Vol. 33, Page 2021-2032, Year 1994
Publish dateApr 15, 1994 (structure data deposition date)
AuthorsBohren, K.M. / Grimshaw, C.E. / Lai, C.J. / Harrison, D.H. / Ringe, D. / Petsko, G.A. / Gabbay, K.H.
External linksBiochemistry / PubMed:8117659
MethodsX-ray diffraction
Resolution1.76 Å
Structure data

PDB-2acu:
TYROSINE-48 IS THE PROTON DONOR AND HISTIDINE-110 DIRECTS SUBSTRATE STEREOCHEMICAL SELECTIVITY IN THE REDUCTION REACTION OF HUMAN ALDOSE REDUCTASE: ENZYME KINETICS AND THE CRYSTAL STRUCTURE OF THE Y48H MUTANT ENZYME
Method: X-RAY DIFFRACTION / Resolution: 1.76 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-CIT:
CITRIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE

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