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Structure paper

TitleInactivation of subtilisin Carlsberg by N-((tert-butoxycarbonyl)alanylprolylphenylalanyl)-O-benzolhydroxyl- amine: formation of a covalent enzyme-inhibitor linkage in the form of a carbamate derivative.
Journal, issue, pagesBiochemistry, Vol. 33, Page 10535-10544, Year 1994
Publish dateMar 2, 1994 (structure data deposition date)
AuthorsSteinmetz, A.C. / Demuth, H.U. / Ringe, D.
External linksBiochemistry / PubMed:8068694
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-1scn:
INACTIVATION OF SUBTILISIN CARLSBERG BY N-(TERT-BUTOXYCARBONYL-ALANYL-PROLYL-PHENYLALANYL)-O-BENZOL HYDROXYLAMINE: FORMATION OF COVALENT ENZYME-INHIBITOR LINKAGE IN THE FORM OF A CARBAMATE DERIVATIVE
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-0EF:
N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(carboxyamino)-2-phenylethyl]-L-prolinamide

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • bacillus licheniformis (bacteria)
Keywordshydrolase/hydrolase INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / SERINE PROTEINASE

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