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Title | Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones. |
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Journal, issue, pages | J. Med. Chem., Vol. 37, Page 3313-3326, Year 1994 |
Publish date | Nov 22, 1994 (structure data deposition date) |
Authors | Bernstein, P.R. / Andisik, D. / Bradley, P.K. / Bryant, C.B. / Ceccarelli, C. / Damewood Jr., J.R. / Earley, R. / Edwards, P.D. / Feeney, S. / Gomes, B.C. ...Bernstein, P.R. / Andisik, D. / Bradley, P.K. / Bryant, C.B. / Ceccarelli, C. / Damewood Jr., J.R. / Earley, R. / Edwards, P.D. / Feeney, S. / Gomes, B.C. / Kosmider, B.J. / Steelman, G.B. / Thomas, R.M. / Vacek, E.P. / Veale, C.A. / Williams, J.C. / Wolanin, D.J. / Woolson, J.A. |
External links | J. Med. Chem. / PubMed:7932559 |
Methods | X-ray diffraction |
Resolution | 1.8 Å |
Structure data | PDB-1eas: |
Chemicals | ChemComp-NA: ChemComp-SO4: ChemComp-TFK: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE (SERINE PROTEASE) |