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-Structure paper
Title | Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. |
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Journal, issue, pages | J. Biol. Chem., Vol. 270, Page 5057-5064, Year 1995 |
Publish date | Jan 25, 1995 (structure data deposition date) |
Authors | Lewis, W.S. / Cody, V. / Galitsky, N. / Luft, J.R. / Pangborn, W. / Chunduru, S.K. / Spencer, H.T. / Appleman, J.R. / Blakley, R.L. |
External links | J. Biol. Chem. / PubMed:7890613 |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | PDB-1dlr: PDB-1dls: |
Chemicals | ChemComp-NDP: ChemComp-MXA: ChemComp-HOH: ChemComp-MTX: |
Source |
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Keywords | OXIDOREDUCTASE / OXIDO-REDUCTASE |