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TitleNonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
Journal, issue, pagesJ. Med. Chem., Vol. 38, Page 98-108, Year 1995
Publish dateNov 22, 1994 (structure data deposition date)
AuthorsVeale, C.A. / Bernstein, P.R. / Bryant, C. / Ceccarelli, C. / Damewood Jr., J.R. / Earley, R. / Feeney, S.W. / Gomes, B. / Kosmider, B.J. / Steelman, G.B. ...Veale, C.A. / Bernstein, P.R. / Bryant, C. / Ceccarelli, C. / Damewood Jr., J.R. / Earley, R. / Feeney, S.W. / Gomes, B. / Kosmider, B.J. / Steelman, G.B. / Thomas, R.M. / Vacek, E.P. / Williams, J.C. / Wolanin, D.J. / Woolson, S.
External linksJ. Med. Chem. / PubMed:7837246
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-1eat:
NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-TFI:
2-[5-METHANESULFONYLAMINO-2-(4-AMINOPHENYL)-6-OXO-1,6-DIHYDRO-1-PYRIMIDINYL]-N-(3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXOPROPYL)ACETAMIDE

ChemComp-HOH:
WATER

Source
  • sus scrofa (pig)
KeywordsHYDROLASE (SERINE PROTEASE)

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