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-Structure paper
Title | Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones. |
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Journal, issue, pages | J. Med. Chem., Vol. 38, Page 98-108, Year 1995 |
Publish date | Nov 22, 1994 (structure data deposition date) |
![]() | Veale, C.A. / Bernstein, P.R. / Bryant, C. / Ceccarelli, C. / Damewood Jr., J.R. / Earley, R. / Feeney, S.W. / Gomes, B. / Kosmider, B.J. / Steelman, G.B. ...Veale, C.A. / Bernstein, P.R. / Bryant, C. / Ceccarelli, C. / Damewood Jr., J.R. / Earley, R. / Feeney, S.W. / Gomes, B. / Kosmider, B.J. / Steelman, G.B. / Thomas, R.M. / Vacek, E.P. / Williams, J.C. / Wolanin, D.J. / Woolson, S. |
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Methods | X-ray diffraction |
Resolution | 2 Å |
Structure data | ![]() PDB-1eat: |
Chemicals | ![]() ChemComp-NA: ![]() ChemComp-SO4: ![]() ChemComp-TFI: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE (SERINE PROTEASE) |