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Structure paper

TitleStructural basis of drug resistance for the V82A mutant of HIV-1 proteinase.
Journal, issue, pagesNat. Struct. Biol., Vol. 2, Page 244-249, Year 1995
Publish dateNov 17, 1994 (structure data deposition date)
AuthorsBaldwin, E.T. / Bhat, T.N. / Liu, B. / Pattabiraman, N. / Erickson, J.W.
External linksNat. Struct. Biol. / PubMed:7773792
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-1hvs:
STRUCTURAL BASIS OF DRUG RESISTANCE FOR THE V82A MUTANT OF HIV-1 PROTEASE: BACKBONE FLEXIBILITY AND SUBSITE REPACKING
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-A77:
N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE (ACID PROTEASE)

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