Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Diversity of electron-bifurcating CO-fixing supercomplexes in methanogens.
Journal, issue, pages	Sci Adv, Vol. 12, Issue 38, Page eaed3711, Year 2026
Publish date	Sep 18, 2026
Authors	Pablo San Segundo-Acosta / Shunsuke Nomura / Joao Pedro Fernandes-Queiroz / Evgenii Protasov / Jörg Kahnt / Masanori Kaneko / Georg Hochberg / Seigo Shima / Bonnie J Murphy /
PubMed Abstract	In the hydrogenotrophic methanogenic pathway, formylmethanofuran dehydrogenase (Fmd) reduces and fixes CO, driven by low-potential electrons provided by electron-bifurcating heterodisulfide reductase ...In the hydrogenotrophic methanogenic pathway, formylmethanofuran dehydrogenase (Fmd) reduces and fixes CO, driven by low-potential electrons provided by electron-bifurcating heterodisulfide reductase (Hdr) complexed with electron-donating proteins such as Mvh hydrogenase. Here, we report the structure of a C2-symmetric (Mvh-Hdr)-Fmd supercomplex from a Class I methanogen, , which is architecturally different from the previously reported ring-shaped D3-symmetric supercomplex of a methanogen belonging to phylogenetically distinct Class II methanogens. In this C2-symmetric form, the redox active sites of Hdr and Fmd are connected by two MvhB polyferredoxins, whose branching electron paths appear to be available for electron transfer to/from other partners. The ancestral form was likely C2 symmetric, whereas D3-symmetric supercomplexes were acquired by horizontal gene transfer, a transition probably helpful for growth in substrate-poor environments.
External links	Sci Adv / PubMed:42748252 / PubMed Central
Methods	EM (single particle)
Resolution	2.02 - 3.42 Å
Structure data	EMDB-55269: Focused map of the FmdABCFG(1) unit of the Mvh-Hdr-Fmd complex of M. marburgensis Method: EM (single particle) / Resolution: 2.02 Å EMDB-55270: Focused map of the MvhB subunit of the Mvh-Hdr-Fmd complex of M. marburgensis Method: EM (single particle) / Resolution: 2.47 Å EMDB-55271: Focused map of the FmdABCFG(2) unit of the Mvh-Hdr-Fmd complex of M. marburgensis Method: EM (single particle) / Resolution: 2.19 Å EMDB-55272: Focused map of the FmdF dimer unit of the Mvh-Hdr-Fmd complex of M. marburgensis Method: EM (single particle) / Resolution: 2.12 Å EMDB-55273: Focused map of the C-terminus of the MvhB subunit of the Mvh-Hdr-Fmd complex of M. marburgensis Method: EM (single particle) / Resolution: 2.82 Å EMDB-55274: Consensus map of the mobile arm under state 2 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.19 Å EMDB-55275: MvhAGD-focused map of the mobile arm under state 2 substate b of M. marburgensis Method: EM (single particle) / Resolution: 2.94 Å EMDB-55276: HdrA-focused map of the mobile arm under state 2 substate b of M. marburgensis Method: EM (single particle) / Resolution: 2.94 Å EMDB-55277: HdrBC-focused map of the mobile arm under state 2 substate b of M. marburgensis Method: EM (single particle) / Resolution: 3.07 Å EMDB-55278: Consensus map of the mobile arm under state 2 substate b of M. marburgensis Method: EM (single particle) / Resolution: 3.04 Å EMDB-55279: HdrBC-focused map of the mobile arm under state 1 substate a of M. marburgensis Method: EM (single particle) / Resolution: 3.42 Å EMDB-55280: MvhAGD-focused map of the mobile arm under state 1 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.9 Å EMDB-55281: HdrA-focused map of the mobile arm under state 1 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.8 Å EMDB-55282: MvhAGD-focused map of the mobile arm under state 1 substate b of M. marburgensis Method: EM (single particle) / Resolution: 2.83 Å EMDB-55283: HdrA-focused map of the mobile arm under state 1 substate b of M. marburgensis Method: EM (single particle) / Resolution: 2.82 Å EMDB-55284: Consensus map of the mobile arm under state 1 substate b of M. marburgensis Method: EM (single particle) / Resolution: 3.14 Å EMDB-55285: HdrBC-focused map of the mobile arm under state 1 substate b of M. marburgensis Method: EM (single particle) / Resolution: 3.18 Å EMDB-55286: HdrBC-focused map of the mobile arm under state 2 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.13 Å EMDB-55287: MvhAGD-focused map of the mobile arm under state 2 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.2 Å EMDB-55288: HdrA-focused map of the mobile arm under state 2 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.98 Å EMDB-55289: Consensus map of the mobile arm under state 1 substate a of M. marburgensis Method: EM (single particle) / Resolution: 2.88 Å EMDB-55294: Consensus low resolution map of the flavin-bifurcating CO2-fixing Mvh-Hdr-Fmd supercomplex from Methanothermobacter marburgensis Method: EM (single particle) / Resolution: 2.6 Å 55295 9sw2 EMDB-55295, PDB-9sw2: Structure of the MvhAGD-HdrABC dimer of M. marburgensis under state 2 substate a (composite structure) Method: EM (single particle) / Resolution: 2.19 Å 55296 9sw3 EMDB-55296, PDB-9sw3: Structure of the MvhAGD-HdrABC dimer of M. marburgensis under state 2 substate b (composite structure) Method: EM (single particle) / Resolution: 3.25 Å 55297 9sw4 EMDB-55297, PDB-9sw4: Structure of the MvhAGD-HdrABC dimer of M. marburgensis under state 1 substate a (composite structure) Method: EM (single particle) / Resolution: 2.9 Å 55298 9sw5 EMDB-55298, PDB-9sw5: Structure of the MvhAGD-HdrABC dimer of M. marburgensis under state 1 substate b (composite structure) Method: EM (single particle) / Resolution: 3.29 Å 55299 9sw6 EMDB-55299, PDB-9sw6: Structure of the Mvh-Hdr-Fmd complex of Methanothermobacter marburgensis (composite structure) Method: EM (single particle) / Resolution: 2.7 Å
Chemicals	ChemComp-SF4: IRON/SULFUR CLUSTER ChemComp-FAD: FLAVIN-ADENINE DINUCLEOTIDE / FADYM ChemComp-9S8: Non-cubane [4Fe-4S]-cluster ChemComp-FES: FE2/S2 (INORGANIC) CLUSTER ChemComp-FCO: CARBONMONOXIDE-(DICYANO) IRON ChemComp-NI: NICKEL (II) ION ChemComp-HOH: WATER ChemComp-ZN: Unknown entry ChemComp-MGD: 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE ChemComp-MO: MOLYBDENUM ATOM ChemComp-H2S: HYDROSULFURIC ACID ChemComp-F3S*: FE3-S4 CLUSTER
Source	methanothermobacter marburgensis (archaea) methanothermobacter marburgensis str. marburg (archaea)
Keywords	OXIDOREDUCTASE / hydrogenase / dehydrogenase / polyferredoxin