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Structure paper

TitleCOQ8 chaperones coenzyme Q lipid intermediates through ATP-driven structural gating.
Journal, issue, pagesSci Adv, Vol. 12, Page eaeg1124-eaeg1124, Year 2026
Publish dateJan 12, 2026 (structure data deposition date)
AuthorsGottinger, A. / Malatesta, M. / Nicoll, C.R. / Ansari, G. / Quinodoz, M. / Kaminska, K. / Tang, R.W.C. / Tan, T.E. / Fenner, B.J. / Barberan-Martinez, P. ...Gottinger, A. / Malatesta, M. / Nicoll, C.R. / Ansari, G. / Quinodoz, M. / Kaminska, K. / Tang, R.W.C. / Tan, T.E. / Fenner, B.J. / Barberan-Martinez, P. / Garcia-Garcia, G. / Millan, J.M. / Pfau, M. / Burbach, N.E. / Cecchini, D. / Rivolta, C. / Mattevi, A.
External linksSci Adv / PubMed:42525751
MethodsX-ray diffraction
Resolution2.1 - 2.398 Å
Structure data

PDB-9tvk:
Structure of the Tetrapod Ancestor COQ8B in complex with ADP and 2Mn(II)
Method: X-RAY DIFFRACTION / Resolution: 2.398 Å

PDB-9tvn:
Structure of the Tetrapod Ancestor COQ8A in complex with AMP-PNP and 2Mn(II)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-BR:
BROMIDE ION

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

Source
  • synthetic construct (others)
KeywordsLIPID TRANSPORT / ATPase / CoenzymeQ biosynthesis / atypical kinase / LIPID BINDING PROTEIN

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