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Structure paper

TitleStructural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor.
Journal, issue, pagesActa Crystallogr D Struct Biol, Year 2026
Publish dateAug 19, 2025 (structure data deposition date)
AuthorsPark, J. / Hong, H.R. / Han, S.H. / Song, J. / Son, S.Y. / Choi, S. / Park, S.M. / Lee, W.K. / Jiko, C. / Kim, J.H. ...Park, J. / Hong, H.R. / Han, S.H. / Song, J. / Son, S.Y. / Choi, S. / Park, S.M. / Lee, W.K. / Jiko, C. / Kim, J.H. / Jee, J.G. / Bang, J.K. / Park, I.Y. / Lee, S.J.
External linksActa Crystallogr D Struct Biol / PubMed:42473948
MethodsX-ray diffraction
Resolution1.45 - 2.2 Å
Structure data

PDB-9wdd:
Crystal structure of NAMPT-KPT-7523 complex
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-9wdf:
Crystal structure of PAK4-KPT-7523 complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

PDB-1mbg:
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Nicotinamide phosphoribosyltransferase / STRUCTURAL PROTEIN / Serine/threonine-protein kinase PAK 4

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