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TitleA receptor-centered approach identifies Lom as a LamB-bound superinfection exclusion factor in bacteriophage λ.
Journal, issue, pagesCell Rep, Vol. 45, Issue 7, Page 117691, Year 2026
Publish dateJul 17, 2026
AuthorsXiaofei Ge / Zhiwei Gu / Jiawei Wang /
PubMed AbstractBacteriophages face intense competition within bacterial populations. Although bacteria encode diverse anti-phage mechanisms, strategies protecting virions at the host surface remain poorly ...Bacteriophages face intense competition within bacterial populations. Although bacteria encode diverse anti-phage mechanisms, strategies protecting virions at the host surface remain poorly understood. Here, we develop a receptor-centered discovery approach that captures phage proteins bound to host receptors during infection. Applying this strategy to bacteriophage λ and its outer-membrane receptor LamB, we identify Lom as a phage-encoded outer membrane protein that binds LamB. Structural, biochemical, and functional analyses show that Lom occupies the same LamB surface recognized by the receptor-binding protein gpJ, thereby reducing phage adsorption through receptor occlusion. Ribosome profiling indicates that lom is strongly expressed during late lytic growth and is also expressed during lysogeny, consistent with a role in receptor-level superinfection exclusion. Foldseek analyses identify structurally related Lom-like proteins in diverse temperate phages, raising the possibility that receptor occlusion is a more widespread strategy. These findings establish a framework for discovering receptor-level phage competition mechanisms.
External linksCell Rep / PubMed:42467530
MethodsEM (single particle)
Resolution3.45 Å
Structure data

66201

9wso

EMDB-66201, PDB-9wso:
LamB binding with bacteriophage Lom
Method: EM (single particle) / Resolution: 3.45 Å

Source
  • escherichia phage lambda (virus)
  • shigella sonnei (strain ss046) (bacteria)
KeywordsVIRAL PROTEIN / membrane protein; phage protein; complex

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