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TitleInsights into the Structure and Function of the OTU Protease Virulence Factors from Emerging Human Nairoviruses.
Journal, issue, pagesAcs Infect Dis., Year 2026
Publish dateMar 5, 2026 (structure data deposition date)
AuthorsGonzalez, D.S. / Jalf, A. / Moresco, V. / Garcia, J. / Jaroszewski, L. / Matta, D. / Nguyen, J. / Torres, B. / Bergeron, E. / Godzik, A. / Pegan, S.D.
External linksAcs Infect Dis. / PubMed:42439547
MethodsX-ray diffraction
Resolution1.22 - 1.58 Å
Structure data

PDB-11nq:
Crystal structure of viral OTU domain protease from Songling Virus
Method: X-RAY DIFFRACTION / Resolution: 1.22 Å

PDB-11ns:
Crystal Structure of viral OTU domain protease from Pacific coast tick nairovirus
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

PDB-11ny:
Crystal Structure of viral OTU domain protease from Tacheng Tick Virus 1
Method: X-RAY DIFFRACTION / Resolution: 1.37 Å

PDB-11pu:
Crystal Structure of viral OTU domain protease from Beiji nairovirus
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • orthonairovirus songlingense
  • orthonairovirus dermacentoris
  • orthonairovirus tachengense
  • norwavirus beijiense
KeywordsHYDROLASE / SGLV / L-protein / viral OTu / DeUbiquitinase / deISGlyase / PCTN / TTV1 / BJNV / L protein / norwavirus / virulance factor

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