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TitleDifferent modes of engagement with the nucleosome acidic patch yield distinct functional outcomes.
Journal, issue, pagesNucleic Acids Res, Vol. 54, Issue 13, Year 2026
Publish dateJul 3, 2026
AuthorsUjani Chakraborty / Emma Christina Saccone / Grisel Cruz-Becerra / Laiba F Khan / Nina Arslanovic / Rhiannon Aguilar / Susan L Gloor / Sabrina R Hunt / Heather J Folkwein / Natalia Ledo Husby / Keith E Maier / Matthew R Marunde / Noah K Schomburg / Anup Vaidya / Martis W Cowles / Bryan J Venters / George Kassavetis / Zu-Wen Sun / James T Kadonaga / Jean-Paul Armache / Michael-Christopher Keogh / Jessica K Tyler /
PubMed AbstractThe nucleosome acidic patch is a hub of coordinated engagement by proteins that regulate genomic function. Here, we report that Saccharomyces cerevisiae Dot5 contains an arginine-rich HMGN-like motif ...The nucleosome acidic patch is a hub of coordinated engagement by proteins that regulate genomic function. Here, we report that Saccharomyces cerevisiae Dot5 contains an arginine-rich HMGN-like motif that mediates nucleosome acidic patch binding and is required for the cell growth, DNA repair, and heterochromatin defects exhibited when the protein is overexpressed. The heterologous expression of camelid single-chain antibodies to the nucleosome acidic patch confers a similar range of phenotypes, with the most severe observed when an "arginine-anchor" mode of binding analogous to many endogenous factors is employed. This highlights a delicate balance between nucleosome acidic patch interactors critical for normal cellular function and dysregulated in disease.
External linksNucleic Acids Res / PubMed:42423308 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.17 Å
Structure data

74113

9zen

EMDB-74113, PDB-9zen:
Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1B2
Method: EM (single particle) / Resolution: 3.17 Å

74114

9zeo

EMDB-74114, PDB-9zeo:
Competition for different elements of the nucleosome acidic patch yields distinct functional outcomes. VHH 1G1
Method: EM (single particle) / Resolution: 3.1 Å

Source
  • homo sapiens (human)
  • artificial sequences (others)
KeywordsDE NOVO PROTEIN / chromatin / nucleosome / VHH / antibody / acidic-patch / AP

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