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Structure paper

TitleJanus kinase 2 activation loop as a regulator of catalysis and trans-activation.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 374, Page 153276-153276, Year 2026
Publish dateApr 2, 2026 (structure data deposition date)
AuthorsMiao, Y. / Mykuliak, V.V. / Hubbard, S.R. / Silvennoinen, O. / Hytonen, V. / Haikarainen, T.
External linksInt. J. Biol. Macromol. / PubMed:42409141
MethodsX-ray diffraction
Resolution1.65 - 2.2 Å
Structure data

PDB-29rx:
Crystal structure of JAK2 JH1 in complex with ADP
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-29ry:
The crystal structure of the apo JAK2 kinase domain
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-9t1u:
JAK2-ruxolitinib complex with a phosphorylated activation loop
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-9t1z:
JAK2-ruxolitinib complex with an unphosphorylated activation loop
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-9t20:
JAK2-ruxolitinib complex with Y1007F and Y1008F mutations in the activation loop
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-RXT:
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

ChemComp-MLI:
MALONATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Janus kinase / JAK2 / JH1

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