Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Cryo-EM structures of phage T4 infection intermediate.
Journal, issue, pages	J. Mol. Biol., Page 169938, Year 2026
Publish date	Oct 22, 2025
Authors	Qianqian Shao / Junhua Dong / Aohan Wang / Hongli Hu / Jian Yue / Hongmei Li / Yinyin Li / Qinfen Zhang / Jun Liu / Lei Sun / Andrei Fokine / Venigalla B Rao / Pan Tao / Qianglin Fang /
PubMed Abstract	Myophage is endowed with a sophisticated contractile tail and infection machinery. However, the mechanisms of host recognition, signal transduction, and genome delivery remain poorly understood. ...Myophage is endowed with a sophisticated contractile tail and infection machinery. However, the mechanisms of host recognition, signal transduction, and genome delivery remain poorly understood. Here, we capture a pre-genome-release intermediate of myophage T4 and determine its structure by cryo-electron microscopy. Comparative analysis of this tail-contracted, pre-genome-release intermediate structure with the mature T4 virion and the tail-contracted, post-genome-release structure reveals structural transitions in the tail, tape-measure protein (TMP), baseplate, and long tail fibers that drive genome delivery. Our findings further suggest that tail sheath contraction is coupled to a coordinated repositioning of the viral DNA-TMP complex, potentially facilitating genome translocation via charge-mediated interactions. It appears that the expelled TMP may further reorganize into a putative transmembrane complex that supports genome delivery into the host cytosol.
External links	J. Mol. Biol. / PubMed:42401366
Methods	EM (single particle)
Resolution	3.5 - 3.8 Å
Structure data	64113 9ufn EMDB-64113, PDB-9ufn: Phage T4 tip of the tail tube in post-tail-contraction state (genome-full particle) Method: EM (single particle) / Resolution: 3.8 Å 66504 EMDB Unreleased entry 9x3o EMDB-66504, PDB-9x3o: Phage T4 neck in post-tail-contraction state (genome-full particle) Method: EM (single particle) / Resolution: 3.5 Å 66505 EMDB Unreleased entry 9x3p EMDB-66505, PDB-9x3p: Phage T4 sheath in post-tail-contraction state (genome-full particle) Method: EM (single particle) / Resolution: 3.5 Å 66506 EMDB Unreleased entry 9x3q EMDB-66506, PDB-9x3q: Phage T4 inner baseplate in post-tail-contraction state (genome-full particle) Method: EM (single particle) / Resolution: 3.7 Å 66507 EMDB Unreleased entry 9x3r EMDB-66507, PDB-9x3r: Phage T4 peripheral baseplate in post-tail-contraction state (genome-full particle) Method: EM (single particle) / Resolution: 3.8 Å 66508 EMDB Unreleased entry 9x3s EMDB-66508, PDB-9x3s: Phage T4 tip of the tail tube in post-tail-contraction state (genome-empty particle) Method: EM (single particle) / Resolution: 3.7 Å 66675 EMDB Unreleased entry 9xa3 EMDB-66675, PDB-9xa3: Phage T4 protruding part of the tail tube in post-tail-contraction state (genome-full particle) Method: EM (single particle) / Resolution: 3.54 Å
Source	escherichia phage t4 (virus)
Keywords	VIRAL PROTEIN / Bacteriophage / Myovirus / Phage T4 / tail contraction / phage hub complex / tape-measure protein / genome release / phage neck complex