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TitleMolecular architecture of heterochromatin at the nuclear periphery of primary human cells.
Journal, issue, pagesNat Commun, Vol. 17, Issue 1, Year 2026
Publish dateJul 3, 2026
AuthorsJan Philipp Kreysing / Sergio Cruz-León / Johannes Betz / Carlotta Penzo / Tomáš Majtner / Markus Schreiber / Beata Turoňová / Marina Lusic / Gerhard Hummer / Martin Beck /
PubMed AbstractIn eukaryotes, meters of DNA are packaged into micrometer scale nuclei. Nucleosomes, as the major organizational unit, have been extensively studied in vitro, yet the elaborate 3D structure of ...In eukaryotes, meters of DNA are packaged into micrometer scale nuclei. Nucleosomes, as the major organizational unit, have been extensively studied in vitro, yet the elaborate 3D structure of chromatin inside cells and its distinct oligo-nucleosome arrangements remain poorly resolved. Here, we combine cryo-electron tomography with template matching, subtomogram averaging and molecular simulations to visualize nucleosomes and chromatin structure inside human cells. We confidently assign individual nucleosomes and report their in-situ structure at secondary structure resolution. By predicting the paths of linker DNA, we identify oligo-nucleosome arrangements and uncover higher-order chromatin structures in situ, including a 37-nm wide, elongated but non-fibrous arrangement. In situ structural biology thus reveals the molecular chromatin organization inside cells and sets the stage for 3D genomics.
External linksNat Commun / PubMed:42399220 / PubMed Central
MethodsEM (subtomogram averaging)
Resolution6.8 - 7.4 Å
Structure data

EMDB-58100: In situ chromatosome structure from primary human T cells (C1 symmetry applied)
Method: EM (subtomogram averaging) / Resolution: 7.4 Å

EMDB-58101: In situ chromatosome structure from primary human T cells (C2 symmetry applied)
Method: EM (subtomogram averaging) / Resolution: 6.8 Å

Source
  • Homo sapiens (human)

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