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Title phage tails co-enrich with ex vivo amyloids.
Journal, issue, pagesbioRxiv, Year 2026
Publish dateJun 18, 2026
AuthorsJan-Hannes Schäfer / Robert T O'Neill / Danielle Grotjahn / Evan T Powers / Jeffery W Kelly / Gabriel C Lander /
PubMed AbstractBacteriophages are ubiquitous in the environment and are part of the natural human microbiome. Despite their abundance, the role of the human phagome in health and disease remains poorly understood. ...Bacteriophages are ubiquitous in the environment and are part of the natural human microbiome. Despite their abundance, the role of the human phagome in health and disease remains poorly understood. Here, we identify phage tails in ex vivo amyloid extracts from patients with lysozyme amyloidosis (ALys) and light-chain amyloidosis (AL). Using cryo-EM analysis of the ALys dataset, automated model building, and database searches, we assigned the observed tubular assemblies to a phage tail tube protein (TTP). Although we cannot fully rule out the possibility of contamination, the presence of phage tails raises the question of whether they bind to and are co-purified with amyloid fibrils. These structures may provide further insight into the potential relationship between phage-derived assemblies and amyloid remodeling, with possible implications for future therapeutic strategies in human amyloidosis.
External linksbioRxiv / PubMed:42367858 / PubMed Central
MethodsEM (helical sym.)
Resolution3.5 Å
Structure data

72138

11ok

EMDB-72138: Phage tail tube protein from EMPIAR-11785
PDB-11ok: Phage Tail Tube Protein from ALys extract
Method: EM (helical sym.) / Resolution: 3.5 Å

Source
  • bacteriophage sp. (virus)
KeywordsVIRAL PROTEIN / Helical assembly / phage tail tube protein

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