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TitleStructural and kinetic analysis of human NQO1: Evidence for therapeutic inhibition by racemic warfarin.
Journal, issue, pagesArch. Biochem. Biophys., Vol. 783, Page 110911-110911, Year 2026
Publish dateFeb 2, 2026 (structure data deposition date)
AuthorsAlt, T.B. / Corrigan, M.C. / Krawczykowski, K.J. / Smith, C.O. / Vargas, A.L. / Liu, D. / Moran, G.R.
External linksArch. Biochem. Biophys. / PubMed:42362135
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-10qv:
Crystal Structure of NQO1 Complexed with S-Warfarin
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-SWF:
S-WARFARIN

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsFLAVOPROTEIN / Cytoplasmic flavoprotein / antioxidant

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