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-Structure paper
| Title | Optimization and In Vivo Characterization of a Series of Cbl‐b Inactive-State Inhibitors. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 17, Page 1253-1257, Year 2026 |
| Publish date | Feb 12, 2026 (structure data deposition date) |
 Authors | Lambrecht, M.J. / Liang, J. / Ung, P.M. / Huestis, M.P. / Zhu, B.Y. / Barton, L.M. / Castanedo, G.M. / Zbieg, J.R. / Larouche-Gauthier, R. / Jakalian, A. ...Lambrecht, M.J. / Liang, J. / Ung, P.M. / Huestis, M.P. / Zhu, B.Y. / Barton, L.M. / Castanedo, G.M. / Zbieg, J.R. / Larouche-Gauthier, R. / Jakalian, A. / Leclerc, J.P. / Yadav, A. / Haghshenas, P. / Aubert-Nicol, S. / Ismaili, H. / Zhao, L. / Leblanc, M. / Wang, J. / Wang, S. / Wang, Q. / Garner, T. / Tan, S. / Prangley, M. / Broccatelli, F. / Pang, J. / Murray, J. / Yu, C. / Hsu, P. / Rutz, S. / Kakiuchi-Kiyota, S. / Ishizuka, I. / Leung, D.H. / Kou, P. / Bao, L. / Wang, X. |
 External links | Acs Med. Chem. Lett. / PubMed:42305211 |
| Methods | X-ray diffraction |
| Resolution | 1.77 Å |
| Structure data |  PDB-10zj: |
| Chemicals |  ChemComp-GOL:  ChemComp-ZN:  ChemComp-EDO:  ChemComp-MG:  PDB-1dcc:  ChemComp-HOH: |
| Source |
|
 Keywords | LIGASE/INHIBITOR / Ubiquitin ligase / E3 / inhibitor / LIGASE / LIGASE-INHIBITOR complex |
homo sapiens (human)