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Structure paper

TitleStructural basis for LMBD1-dependent trafficking and cobalamin export of ABCD4.
Journal, issue, pagesNat Commun, Year 2026
Publish dateMar 22, 2026 (structure data deposition date)
AuthorsLiu, Q. / Li, X. / Wu, Y. / Zheng, K. / Zhou, M. / Long, T.
External linksNat Commun / PubMed:42303638
MethodsEM (single particle)
Resolution2.8 - 2.98 Å
Structure data

PDB-24vc:
Structure of lumen-open ABCD4-LMBD1 complex
Method: ELECTRON MICROSCOPY / Resolution: 2.8 Å

PDB-24vd:
Structure of substrate-bound ABCD4-LMBD1 complex
Method: ELECTRON MICROSCOPY / Resolution: 2.83 Å

PDB-24ve:
Structure of cytosol-open ABCD4-LMBD1
Method: ELECTRON MICROSCOPY / Resolution: 2.98 Å

Chemicals

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CLR:
CHOLESTEROL

ChemComp-B12:
COBALAMIN

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Transporter

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