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Structure paper

TitleDouble-Stapled Peptide Scan Yields Potent Fusion Inhibitors of Respiratory Syncytial Virus.
Journal, issue, pagesJ. Med. Chem., Year 2026
Publish dateMar 30, 2026 (structure data deposition date)
AuthorsPidoux, N. / Roh, L. / Nicolet, N. / Marti, R. / Le Rouzic, A. / Prompt, C. / Fix, J. / Duquerroy, S. / Rey, F. / Rameix-Welti, M.A. ...Pidoux, N. / Roh, L. / Nicolet, N. / Marti, R. / Le Rouzic, A. / Prompt, C. / Fix, J. / Duquerroy, S. / Rey, F. / Rameix-Welti, M.A. / Keck, M. / Barbe, P. / Garcin, D. / Mottet-Osman, G. / Larcher, T. / Galloux, M. / Nyanguile, O.
External linksJ. Med. Chem. / PubMed:42203199
MethodsX-ray diffraction
Resolution1.325 - 1.625 Å
Structure data

PDB-29qj:
Respiratory syncytial virus fusion protein N-terminal heptad repeat domain in complex with Double stapled peptide 4/4g
Method: X-RAY DIFFRACTION / Resolution: 1.325 Å

PDB-9ra5:
Respiratory syncytial virus fusion protein N-terminal heptad repeat domain in complex with Double stapled peptide 3/4i
Method: X-RAY DIFFRACTION / Resolution: 1.625 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-K:
Unknown entry

Source
  • human respiratory syncytial virus a
  • human respiratory syncytial virus
KeywordsVIRAL PROTEIN / Human Respiratory Syncytial Virus / Fusion Protein / Fusion Inhibitor / Stapled Peptide / Six Helix Bundle / Complex / ANTIVIRAL PROTEIN

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