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| Title | Discovery of the Orally Bioavailable Isoform Selective Janus Kinase 1 (JAK1) Compound Povorcitinib (INCB054707) for the Treatment of Inflammatory and Autoimmune Diseases. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 69, Page 12830-12852, Year 2026 |
| Publish date | Jan 30, 2026 (structure data deposition date) |
 Authors | Zhuo, J. / Li, Y.L. / Qian, D.Q. / Burns, D.M. / Mei, S. / Rafalski, M. / Xu, M. / Cao, G. / Pan, Y. / Jia, Z. ...Zhuo, J. / Li, Y.L. / Qian, D.Q. / Burns, D.M. / Mei, S. / Rafalski, M. / Xu, M. / Cao, G. / Pan, Y. / Jia, Z. / Jalluri, R. / Epling, L.B. / Fenalti, G. / Deller, M.C. / Procak, J. / Covington, M. / He, X. / Collins, R. / Stubbs, M. / Burke, K. / Oliver, J. / Margulis, A. / Boer, J. / Wynn, R. / Scherle, P. / Diamond, S. / Newton, R. / Zhang, Y. / Metcalf, B. / Yao, W. |
 External links | J. Med. Chem. / PubMed:42202255 |
| Methods | X-ray diffraction |
| Resolution | 1.54 - 1.59 Å |
| Structure data |  PDB-10pi:  PDB-10pj: |
| Chemicals |  ChemComp-EDO:  PDB-1c68:  ChemComp-DMS:  ChemComp-HOH:  ChemComp-MLA: |
| Source |
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 Keywords | TRANSFERASE / Inhibitor / Kinase / Complex |
homo sapiens (human)