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-Structure paper
| Title | Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Year 2026 |
| Publish date | Feb 4, 2026 (structure data deposition date) |
 Authors | Josien, H. / Nair, A.G. / Ding, F.X. / Guo, Y. / Chen, Y.H. / Rao, A.U. / Liu, J. / Tong, L. / Sun, Z. / Lo, M.M. ...Josien, H. / Nair, A.G. / Ding, F.X. / Guo, Y. / Chen, Y.H. / Rao, A.U. / Liu, J. / Tong, L. / Sun, Z. / Lo, M.M. / Tucker, T.J. / Embrey, M.W. / Shahripour, A. / Wu, C. / Bianchi, E. / Branca, D. / Kuethe, J.T. / Lee, J. / Thaisrivongs, D.A. / Bulger, P.G. / Zhu, X. / Ha, S.N. / Johnston, J.M. / Klein, D.J. / Orth, P. / Hong, M.R. / Buevich, A.V. / Gao, Q. / Zokian, H.J. / Koeplinger, K.A. / Tracy, R.W. / Hafey, M.J. / Buist, N. / Bueters, T. / Alleyne, C. / Bass, A. / Campeau, L.C. / Johns, D.G. / Garbaccio, R.M. / Vachal, P. / Walji, A. / Wood, H.B. |
 External links | J. Med. Chem. / PubMed:42201324 |
| Methods | X-ray diffraction |
| Resolution | 1.828 Å |
| Structure data |  PDB-10sb: |
| Chemicals |  ChemComp-GOL:  PDB-1c8p:  ChemComp-GOA:  ChemComp-HOH: |
| Source |
|
 Keywords | HYDROLASE / CHOLESTEROL / LDL RECEPTOR / EGFA DOMAIN |
homo sapiens (human)