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Structure paper

TitleDual targeting of inhibitory EGFR epitopes with synthetic antibodies in therapeutic-resistant cancers.
Journal, issue, pagesProtein Sci., Vol. 35, Page e70645-e70645, Year 2026
Publish dateNov 18, 2025 (structure data deposition date)
AuthorsAdams, J.J. / Mallette, E. / London, M. / Liang, R.J. / van Dyk, D. / Pavlovic, Z. / Pot, I. / Geyer, C.R. / Bruce, H.A. / Blazer, L.L. ...Adams, J.J. / Mallette, E. / London, M. / Liang, R.J. / van Dyk, D. / Pavlovic, Z. / Pot, I. / Geyer, C.R. / Bruce, H.A. / Blazer, L.L. / Hokanson, C.A. / Suits, M.D.L. / Singer, A.U. / Sidhu, S.S.
External linksProtein Sci. / PubMed:42178617
MethodsX-ray diffraction
Resolution2.4 - 3.06 Å
Structure data

PDB-9z9e:
Structure of FabS1CE2_ER-3c in complex with the extracellular region of EGFR
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-9z9f:
Structure of FabS1CE2_ER-2a in complex with the extracellular region of EGFR
Method: X-RAY DIFFRACTION / Resolution: 3.06 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SCN:
THIOCYANATE ION

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / epidermal growth factor receptor / high-affinity antibody / domain 3 / epidermal growth factor / inhibition / dimerization arm

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