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TitleLaroprovstat, the First Oral Small-Molecule PCSK9 Inhibitor for the Treatment of Hypercholesterolemia: Results From a Randomized, Single-Blind, Placebo-Controlled Phase 1 Trial in Treatment-Naive Patients.
Journal, issue, pagesCirculation, Vol. 153, Page 1999-2010, Year 2026
Publish dateJan 13, 2025 (structure data deposition date)
AuthorsVega, R.B. / O'Mahony, G. / Barbour, A.M. / Yu, H. / Knochel, J. / Brengdahl, J. / Hochdorfer, T. / Bergenholm, L. / Toppner Carlsson, E. / Ahnmark, A. ...Vega, R.B. / O'Mahony, G. / Barbour, A.M. / Yu, H. / Knochel, J. / Brengdahl, J. / Hochdorfer, T. / Bergenholm, L. / Toppner Carlsson, E. / Ahnmark, A. / Underwood, C.R. / Rudvik, A. / Carter, D. / Laru, J. / Gutgsell, A. / Twaddle, L. / Garkaviy, P. / Bogstedt, A. / Hurt-Camejo, E. / Miliotis, T. / Ryaboshapkina, M. / Hober, A. / Hubbard, B. / Serrano-Wu, M. / Kaushik, V. / Geschwindner, S. / McCarthy, M.C. / Linden, D. / Rosenmeier, J.B.
External linksCirculation / PubMed:42137960
MethodsX-ray diffraction
Resolution1.432 - 1.759 Å
Structure data

PDB-9hz3:
PCSK9 AZD0780 complex
Method: X-RAY DIFFRACTION / Resolution: 1.432 Å

PDB-9szy:
PCSK9 CTD fragment structure
Method: X-RAY DIFFRACTION / Resolution: 1.759 Å

Chemicals

PDB-1iyr:
NMR Structure Ensemble Of Dff-C Domain

ChemComp-HOH:
WATER

PDB-1jsm:
STRUCTURE OF H5 AVIAN HAEMAGGLUTININ

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / PCSK9 AZD0780 / CHAPERONE / PCSK9 / CTD / fragment

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