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TitleHuman neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins.
Journal, issue, pagesCell Host Microbe, Vol. 34, Page 1067-1081.e12, Year 2026
Publish dateAug 14, 2025 (structure data deposition date)
AuthorsAcciani, M. / Zyla, D. / Niemeyer, G. / Harkins, S. / Parekh, D. / Pawlack, E. / Lacarbonara, D. / Kansara, D. / Ackerman, M.E. / Niewiesk, S. ...Acciani, M. / Zyla, D. / Niemeyer, G. / Harkins, S. / Parekh, D. / Pawlack, E. / Lacarbonara, D. / Kansara, D. / Ackerman, M.E. / Niewiesk, S. / Porotto, M. / Hastie, K.M. / Saphire, E.O.
External linksCell Host Microbe / PubMed:42102820
MethodsEM (single particle)
Resolution2.3 - 3.25 Å
Structure data

PDB-9q1z:
Structure of the Measles virus Hemagglutinin ectodomain in complex with neutralizing antibody 1C02
Method: ELECTRON MICROSCOPY / Resolution: 3.05 Å

PDB-9q20:
Structure of the Measles virus Hemagglutinin ectodomain in complex with neutralizing antibody 1C08
Method: ELECTRON MICROSCOPY / Resolution: 3.25 Å

PDB-9q24:
Structure of the Measles virus Hemagglutinin ectodomain in complex with two neutralizing antibodies 1C08 and 4D08
Method: ELECTRON MICROSCOPY / Resolution: 3.25 Å

PDB-9q26:
Structure of the Measles virus Fusion glycoprotein ectodomain in complex with two neutralizing antibodies 4F09 and 3A12
Method: ELECTRON MICROSCOPY / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-MAN:
alpha-D-mannopyranose

Source
  • homo sapiens (human)
  • measles morbillivirus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / VIRAL PROTEIN / glycoprotein / immune system / measles / high-resolution / ectodomain / attachment / antibody / complex / VIRAL PROTEIN-IMMUNE SYSTEM complex / fusion

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