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Structure paper

TitleRNA-binding landscape of amiloride: large-scale profiling and structural basis of U-U mismatch recognition.
Journal, issue, pagesRsc Chem Biol, Year 2026
Publish dateFeb 9, 2026 (structure data deposition date)
AuthorsTsuzuki, K. / Onizuka, K. / Okada, M. / Nagasawa, R. / Miyashita, E. / Komatsu, K.R. / Saito, H. / Kondo, J. / Nagatsugi, F.
External linksRsc Chem Biol / PubMed:42100640
MethodsX-ray diffraction
Resolution2.59 - 2.9 Å
Structure data

PDB-23jy:
pre-miR-6074 internal loop
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-23jz:
pre-miR-6074 internal loop in complex with amiloride (Form 1)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-23ka:
pre-miR-6074 internal loop in complex with amiloride (Form 2)
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-AMR:
3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CAD:
CACODYLIC ACID

Source
  • synthetic construct (others)
KeywordsRNA / pre-miR-6074

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