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-Structure paper
| Title | Discovery of MK-1088 as a Potent A 2A /A 2B Adenosine Receptor Dual-Antagonist for Cancer Immunotherapy. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 69, Page 10338-10359, Year 2026 |
| Publish date | Jan 25, 2026 (structure data deposition date) |
 Authors | Zhang, Y. / Hennessy, E. / Larsen, M.A. / Hao, J. / Pan, J. / Mansoor, U.F. / Sather, A. / Brill, Z.G. / Rico, L. / Swaminathan, U. ...Zhang, Y. / Hennessy, E. / Larsen, M.A. / Hao, J. / Pan, J. / Mansoor, U.F. / Sather, A. / Brill, Z.G. / Rico, L. / Swaminathan, U. / Moreno, J. / Vara, B.A. / Ranganath, S. / Palmieri, A. / Ogunbodede, O. / Barry, E.R. / Hinton, M.C. / Daublain, P. / Gupta, P. / Chatterjee, M. / Rottey, S. / Presland, J. / Hill, A.D. / Dewey, W.J. / Schneider, S.E. / Ciaccio, P.J. / Otte, K.M. / Rindgen, D. / Tatosian, D. / Turnbull, B.W.H. / Silverman, S.M. / Chobanian, H. / Krishnamurthy, H. / Pang, L. / Wnek, R. / Afshar, R. / Crowley, S. / Miller, A. / O'Neil, J. / Chrencik, J. / Plummer, C.W. / Ali, A. / Cumming, J. / DeMong, D.E. |
 External links | J. Med. Chem. / PubMed:42084562 |
| Methods | X-ray diffraction |
| Resolution | 2.59 Å |
| Structure data |  PDB-10kt: |
| Chemicals |  ChemComp-NA:  PDB-1c5s:  ChemComp-CLR:  ChemComp-OLA:  ChemComp-OLC:  ChemComp-OLB:  ChemComp-PEG:  ChemComp-HOH: |
| Source |
|
 Keywords | MEMBRANE PROTEIN / Class A GPCR / antagonist |
homo sapiens (human)
escherichia coli (E. coli)