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TitleIntegrative Approach to Develop and Characterize Antibodies against the Cancer-Associated Antigen Sialyl Lewis A (CA 19-9).
Journal, issue, pagesJacs Au, Vol. 6, Page 2274-2287, Year 2026
Publish dateJan 31, 2025 (structure data deposition date)
AuthorsFreitag, A. / Khilji, S.K. / Nedielkov, R. / M Kumar, S. / Krummhaar, M. / Arndt, J. / Moreira, G.M.S.G. / Luhle, J. / Goerdeler, F. / Kamphues, C. ...Freitag, A. / Khilji, S.K. / Nedielkov, R. / M Kumar, S. / Krummhaar, M. / Arndt, J. / Moreira, G.M.S.G. / Luhle, J. / Goerdeler, F. / Kamphues, C. / Mroginski, M.A. / Roth, C. / Seeberger, P.H. / Moller, H.M. / Moscovitz, O.
External linksJacs Au / PubMed:42063835
MethodsX-ray diffraction
Resolution1.86 - 2.96 Å
Structure data

PDB-9i6q:
Structure of Fab-Fragment GB11 agains tumour associated carbohydrate antigens.
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

PDB-9i9h:
Structure of FAB-fragment GB11 in complex with Sialyl Lewis A
Method: X-RAY DIFFRACTION / Resolution: 2.96 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

ChemComp-SIA:
N-acetyl-alpha-neuraminic acid

ChemComp-GAL:
beta-D-galactopyranose

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Antibody / FAB fragment / apo / Carbohydrate / complex

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