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TitleCovalent Targeting of Histidine Residues: A Ligand-First Approach.
Journal, issue, pagesJ. Med. Chem., Vol. 69, Page 10201-10212, Year 2026
Publish dateNov 7, 2025 (structure data deposition date)
AuthorsAlboreggia, G. / Atienza, E.L. / Muzzarelli, K. / Assar, Z. / Pellecchia, M.
External linksJ. Med. Chem. / PubMed:42054250
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-9z3v:
Histidine-covalent 165G1 targeting hMcl-1
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsAPOPTOSIS / Histidine-covalent stapled alpha-helical peptides

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