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Structure paper

TitleGlycerol-driven TNAP activation in thermogenesis and mineralization.
Journal, issue, pagesNature, Year 2026
Publish dateFeb 9, 2026 (structure data deposition date)
AuthorsHussain, M.F. / Krishnan, S.S. / Carroll, B.L. / Samborska, B. / Mousa, A. / Williamson, A. / Delgado-Martin, M. / Srinivasu, B.Y. / Bunk, J. / Rahbani, J.F. ...Hussain, M.F. / Krishnan, S.S. / Carroll, B.L. / Samborska, B. / Mousa, A. / Williamson, A. / Delgado-Martin, M. / Srinivasu, B.Y. / Bunk, J. / Rahbani, J.F. / Oppong, A. / Roesler, A. / Kaiser, Z. / Ersin, M. / Zhang, Q. / Guerra Martinez, M. / Shaw, A. / Cheng, J. / Klemets, H. / Illes, K.K. / DeMambro, V.E. / Rosen, C.J. / Millan, J.L. / Wales, T.E. / Langenberg, C. / McKee, M.D. / Guarne, A. / Kazak, L.
External linksNature / PubMed:42020733
MethodsX-ray diffraction
Resolution2.12 - 2.71 Å
Structure data

PDB-10tv:
Tissue Non-specific Alkaline Phosphatase -S110A bound to phosphocreatine
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-10tw:
Tissue Non-specific Alkaline Phosphatase -D370G bound to phosphocreatine
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

PDB-10tx:
Tissue Non-specific Alkaline Phosphatase -S110A bound to PPi
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-10ty:
Tissue Non-specific Alkaline Phosphatase -S110A bound to PPi with ethylene glycol
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-10tz:
Tissue Non-specific Alkaline Phosphatase -S110A bound to ATP
Method: X-RAY DIFFRACTION / Resolution: 2.71 Å

Chemicals


ChemComp, No image

ChemComp-XDC:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-PO4:
PHOSPHATE ION

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-FLC:
CITRATE ANION

ChemComp-HOH:
WATER

ChemComp-POP:
PYROPHOSPHATE 2-

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / TNAP

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