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TitleMitochondrial respirasome-like supercomplexes support metabolic flexibility in yeast.
Journal, issue, pagesNat Commun, Year 2026
Publish dateApr 21, 2026
AuthorsMazzen H Eldeeb / Zoe Cosner / Andreas Carlström / Jeffri-Noelle Mays / Gabriella F Rodriguez / Jens Berndtsson / Martin Ott / Flavia Fontanesi /
PubMed AbstractThe mitochondrial respiratory chain (MRC) complexes, crucial for aerobic energy transduction in eukaryotes, form conserved higher-order structures called supercomplexes (SCs). The elucidation of SC ...The mitochondrial respiratory chain (MRC) complexes, crucial for aerobic energy transduction in eukaryotes, form conserved higher-order structures called supercomplexes (SCs). The elucidation of SC physiological relevance is critical for our understanding of mitochondrial function and bioenergetics but has been hindered by the limited availability of experimental models isolating SC formation as the sole variable. In baker's yeast, SCs comprise IIIIV and IIIIV configurations, which enhance respiratory rates by facilitating cytochrome c diffusion along the SC surface. However, the roles of distinct SC conformations and MRC plasticity remain unclear. To address these questions, we engineered a yeast strain expressing a covalently-linked IIIIV SC, structurally like the wild-type. Expression of this tethered SC supports robust respiratory activity but selectively impacts cytosolic NADH-driven respiration, due to distinct interactions with the NADH dehydrogenase Nde1. We propose that in yeast mitochondria, substrate-specific respirasome-like SCs contribute to the optimization of electron fluxes and support metabolic flexibility.
External linksNat Commun / PubMed:42014734
MethodsEM (single particle)
Resolution2.73 - 2.78 Å
Structure data

EMDB-44774: Tethered respiratory III2IV2 supercomplex from Saccharomyces cerevisiae, CIVa local refinement
Method: EM (single particle) / Resolution: 2.73 Å

EMDB-44775: Tethered respiratory III2IV2 supercomplex from Saccharomyces cerevisiae, CIVb local refinement
Method: EM (single particle) / Resolution: 2.78 Å

Source
  • Saccharomyces cerevisiae (brewer's yeast)

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