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Structure paper

TitleAllelic variation alters expression and antigen presentation of MR1 allomorphs.
Journal, issue, pagesJ. Biol. Chem., Vol. 302, Page 111470-111470, Year 2026
Publish dateAug 29, 2025 (structure data deposition date)
AuthorsNelson, A.G. / Letoga, V. / Lee, C.Z.Q. / Samer, C. / Li, S. / Meehan, L.J. / McWilliam, H.E.G. / Gherardin, N.A. / Abendroth, A. / Villadangos, J.A. ...Nelson, A.G. / Letoga, V. / Lee, C.Z.Q. / Samer, C. / Li, S. / Meehan, L.J. / McWilliam, H.E.G. / Gherardin, N.A. / Abendroth, A. / Villadangos, J.A. / Slobedman, B. / Corbett, A.J. / McCluskey, J. / Rossjohn, J. / Chen, Z. / Souter, M.N.T. / Awad, W.
External linksJ. Biol. Chem. / PubMed:42001947
MethodsX-ray diffraction
Resolution2.1 - 3 Å
Structure data

PDB-9y0t:
Crystal structure of human MAIT A-F7 TCR-MR1*02-5-OP-RU complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-9y0u:
Crystal structure of human MAIT A-F7 TCR-MR1*03-5-OP-RU complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-9y0v:
Crystal Structure of human MAIT A-F7 TCR-MR1*04 complex
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-9y0w:
Crystal Structure of human MAIT A-F7 TCR-MR1*05-5-OP-RU complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-Q87:
1-deoxy-1-({2,6-dioxo-5-[(E)-(2-oxopropylidene)amino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-ACY:
ACETIC ACID

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / MAIT TCR / MR1 / metabolite presentation

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