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TitleMESH1 functions as a metazoan PAPS phosphatase to regulate sulfation.
Journal, issue, pagesNat. Chem. Biol., Year 2026
Publish dateJul 2, 2024 (structure data deposition date)
AuthorsLin, C.C. / Rose, J. / Zhang, A. / Mirando, A.J. / Mestre, A.A. / Ding, C.C. / Liao, Y. / Chen, S.Y. / Setayeshpour, Y. / Wu, J. ...Lin, C.C. / Rose, J. / Zhang, A. / Mirando, A.J. / Mestre, A.A. / Ding, C.C. / Liao, Y. / Chen, S.Y. / Setayeshpour, Y. / Wu, J. / Li, Z. / Yan, D. / Hilton, M.J. / Zhou, P. / Chi, J.T.
External linksNat. Chem. Biol. / PubMed:41963701
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-9chy:
Crystal structure of the human MESH1 (D66K)-PAPS complex
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-PPS:
3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / phosphatase / PAPS

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