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| Title | Optimization of Covalent 6-Cyanoquinazoline KRAS G12C Inhibitors for the Treatment of Solid Tumors. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 69, Page 9163-9195, Year 2026 |
| Publish date | Jan 29, 2026 (structure data deposition date) |
 Authors | Waldo, J.P. / Krawczuk, P.J. / Kelly, C.B. / Callas, C.G. / Cisar, J.S. / Eccles, W. / Guerrero, C.A. / Hack, M.D. / Jones, W.M. / Keohane, C.E. ...Waldo, J.P. / Krawczuk, P.J. / Kelly, C.B. / Callas, C.G. / Cisar, J.S. / Eccles, W. / Guerrero, C.A. / Hack, M.D. / Jones, W.M. / Keohane, C.E. / Li, L.S. / Meegalla, S. / Padilla-Salinas, R. / Rosano, R.J. / Shimkin, K.W. / Simonnet, Y.R.F. / Sitkoff, D. / Sookezian, A. / Winters, M.P. / Bush, T.L. / Cheung, S.T. / Del Rosario, A.M. / Hansen, R. / Janes, M.R. / Janjua, H. / Kazmi, F. / Kirkpatrick, R. / La, D. / Lenhart, R. / Lorenzi, M.V. / Liu, Y. / Mesens, N. / Milligan, C.M. / Murrey, H. / Peters, U. / Ren, P. / Richter, M. / Rizzolio, M. / Rao, S. / Shaffer, P. / Stratton, C.F. / Szewczuk, L.M. / Wen, J. / Wong, V. / Yanovich, C. / Laquerre, S. / Edwards, J.P. / Leonard, K.A. |
 External links | J. Med. Chem. / PubMed:41921095 |
| Methods | X-ray diffraction |
| Resolution | 1.5 - 1.52 Å |
| Structure data |  PDB-10nu:  PDB-10nv: |
| Chemicals |  ChemComp-CA:  PDB-1c6y:  ChemComp-GOL:  ChemComp-GDP:  ChemComp-HOH:  PDB-1c60: |
| Source |
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 Keywords | ONCOPROTEIN / KRAS / SMALL GTPASE / INHIBITOR Complex |
homo sapiens (human)