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Structure paper

TitleStructure of Factor VII Gla domain bound to EPCR.
Journal, issue, pagesBlood Adv, Year 2026
Publish dateDec 8, 2025 (structure data deposition date)
AuthorsLopez-Sagaseta, J. / Dichiara-Rodriguez, M.G.
External linksBlood Adv / PubMed:41855508
MethodsX-ray diffraction
Resolution1.55 - 3 Å
Structure data

PDB-9tjx:
Structure of factor VII Gla domain bound to EPCR
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-9tro:
Factor VII Gla domain, X-ray structure
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-PTY:
PHOSPHATIDYLETHANOLAMINE / phospholipid*YM

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / Factor VII / activated factor VII / EPCR / GLA DOMAIN / COMPLEX / CALCIUM IONS / PROTEIN BINDING / Factor VIIa; coagulation; hemophilia; bleeding; EPCR; complex

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