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TitleNatural Glycoside OSW-1 Targets Glycolytic Enzyme Enolase 1 to Reprogram Tumor Metabolism via Glycolytic Blockade.
Journal, issue, pagesAcs Chem. Biol., Vol. 21, Page 790-800, Year 2026
Publish dateOct 10, 2025 (structure data deposition date)
AuthorsXia, Y. / Xia, M. / Dai, Z. / Fang, P. / Wang, J. / Zhu, D. / Luo, C. / Xu, H. / Yu, B.
External linksAcs Chem. Biol. / PubMed:41855411
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-9x4f:
Crystal structure of tetrameric alpha-enolase with asymmetric flexible active sites
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / Conformational change / Asymmetric

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