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TitleCrystal Structure of Mengla Virus Nucleoprotein Bound by a Poorly Cross-Reactive Anti-Marburg Virus Nanobody Highlights a Single Amino Acid Affinity Switch, a Feature Also Evident in Dehong Virus.
Journal, issue, pagesAcs Infect Dis., Vol. 12, Page 1104-1121, Year 2026
Publish dateFeb 12, 2026 (structure data deposition date)
AuthorsSherwood, L.J. / Taylor, A.B. / Olsen, S.K. / Hayhurst, A.
External linksAcs Infect Dis. / PubMed:41760080
MethodsX-ray diffraction
Resolution1.65 Å
Structure data

PDB-10zo:
Crystal structure of Mengla virus nucleoprotein bound by a cross-reactive anti-Marburg virus nanobody
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • lama glama (llama)
  • dianlovirus menglaense
KeywordsIMMUNE SYSTEM/VIRAL PROTEIN / Filovirus / Mengla / Marburg / nucleoprotein / nanobody / IMMUNE SYSTEM / IMMUNE SYSTEM-VIRAL PROTEIN complex

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