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Structure paper

TitleStructural basis for sialoglycan recognition by the immune inhibitory receptor Siglec-10.
Journal, issue, pagesStructure, Vol. 34, Page 768-777.e5, Year 2026
Publish dateApr 13, 2025 (structure data deposition date)
AuthorsMedina, E. / Mason, C. / Tran, T.H. / Julia, E.P. / Ming, Q. / Taibi, L.M. / Hwu, P. / Maute, R.L. / Burg, J.S. / Luca, V.C.
External linksStructure / PubMed:41747717
MethodsX-ray diffraction
Resolution2.7 - 3.39 Å
Structure data

PDB-9o6j:
Structure of Siglec-10 in complex with 2,3-Sialyllactose
Method: X-RAY DIFFRACTION / Resolution: 3.39 Å

PDB-9o6n:
Structure of Siglec-10
Method: X-RAY DIFFRACTION / Resolution: 2.98 Å

PDB-9o6o:
Structure of SigLec-10 in complex with 2,6-Sialyllactose
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SIA:
N-acetyl-alpha-neuraminic acid

ChemComp-FLC:
CITRATE ANION

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Siglec / Receptor / Sialic Acid

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