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-Structure paper
| Title | Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Pol theta. |
|---|---|
| Journal, issue, pages | Acs Med. Chem. Lett., Vol. 17, Page 433-440, Year 2026 |
| Publish date | Oct 18, 2025 (structure data deposition date) |
Authors | Bubenik, M. / Mader, P. / Orlicky, S. / Perryman, A.L. / Hamel, M. / Godbout, C. / Falgueyret, J.P. / Kurinov, I. / Wong, C. / Gingras, A.C. ...Bubenik, M. / Mader, P. / Orlicky, S. / Perryman, A.L. / Hamel, M. / Godbout, C. / Falgueyret, J.P. / Kurinov, I. / Wong, C. / Gingras, A.C. / Mamane, Y. / Zinda, M. / Morris, S.J. / Gallant, M. / Sfeir, A. / Black, W.C. / Durocher, D. / Zimmermann, M. / Sicheri, F. |
External links | Acs Med. Chem. Lett. / PubMed:41704370 |
| Methods | X-ray diffraction |
| Resolution | 2 - 2.71 Å |
| Structure data | ![]() PDB-9ysh: ![]() PDB-9ysi: |
| Chemicals | ![]() ChemComp-MG: ![]() ChemComp-DG3: ![]() PDB-1czx: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() PDB-1cz4: |
| Source |
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Keywords | DNA BINDING PROTEIN / TRANSFERASE/INHIBITOR / inhibitor / complex / TRANSFERASE-INHIBITOR complex / DNA/TRANSFERASE/INHIBITOR / DNA-TRANSFERASE-INHIBITOR complex |
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homo sapiens (human)
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