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TitleA small molecule PTER-selective inhibitor reduces food intake and body weight.
Journal, issue, pagesBiorxiv, Year 2026
Publish dateNov 20, 2024 (structure data deposition date)
AuthorsFu, S. / Wang, L. / Li, V.L. / Lyu, X. / Wei, W. / Shi, X. / Deng, S. / Barber, J.L. / Tahir, U.A. / Adams, C. ...Fu, S. / Wang, L. / Li, V.L. / Lyu, X. / Wei, W. / Shi, X. / Deng, S. / Barber, J.L. / Tahir, U.A. / Adams, C. / Carson, A. / Hidalgo, B. / Raffield, L.M. / Wilson, J.G. / Razumkov, H. / Xiao, S. / Spaas, J. / Fernandez, D. / Zhang, T. / Gerszten, R.E. / Benson, M.D. / Gray, N.S. / Hinshaw, S.M. / Long, J.Z.
External linksBiorxiv / PubMed:41659642
MethodsX-ray diffraction
Resolution2.4 - 2.8 Å
Structure data

PDB-9efa:
Chemical inhibition of the N-acetyltaurine amidohydrolase PTER reduces food intake and obesity
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-9efb:
Chemical inhibition of the N-acetyltaurine amidohydrolase PTER reduces food intake and obesity
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TAU:
2-AMINOETHANESULFONIC ACID

ChemComp-ACT:
ACETATE ION

Source
  • amphimedon queenslandica (invertebrata)
KeywordsHYDROLASE / N-acetyltaurine amidohydrolase

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