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TitleA highly potent and broadly accessible bispecific nanobody for the treatment of ebola virus infections.
Journal, issue, pagesPLoS Pathog, Vol. 22, Issue 1, Page e1013878, Year 2026
Publish dateJan 27, 2026
AuthorsFan Bu / Gang Ye / Kimberly Morsheimer / Hailey Turner-Hubbard / Brett Eaton / Manu Anantpadma / Khaggeswar Bheemanapally / Chalet Tan / Robert Davey / Fang Li /
PubMed AbstractEbola virus (EBOV) causes recurring outbreaks, with a case fatality rate of about 40%. Currently approved vaccine and antibody therapies face major limitations, including only modest reductions in ...Ebola virus (EBOV) causes recurring outbreaks, with a case fatality rate of about 40%. Currently approved vaccine and antibody therapies face major limitations, including only modest reductions in mortality and restricted accessibility due to their reliance on injection-based delivery and cold-chain transport and storage. To address these challenges, we developed a bispecific nanobody, Nanosota-EB1/EB2-Fc, composed of two nanobodies (camelid-derived single-domain antibodies, Nanosota-EB1 and Nanosota-EB2) that target distinct epitopes on the EBOV glycoprotein (GP) and are fused to a human Fc domain. Through cooperative contributions from both nanobodies, this bispecific nanobody strongly inhibits GP function and effectively overcomes the virus's decoy mechanism. A single dose provided strong protection in EBOV-infected mice, including when administered at late stages of infection. It was also effective when administered intranasally, offering a needle-free delivery option. Furthermore, its high in vitro stability indicates that it can be deployed without refrigeration. Taken together, this novel bispecific nanobody represents a promising next-generation therapeutic for EBOV, combining high potency with broad accessibility.
External linksPLoS Pathog / PubMed:41592114 / PubMed Central
MethodsEM (single particle)
Resolution2.92 Å
Structure data

71328

9p6x

EMDB-71328, PDB-9p6x:
Structure of EBOV glycoprotein in complex with Nanosota-EB1 and EB2
Method: EM (single particle) / Resolution: 2.92 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • Ebola virus - Mayinga, Zaire, 1976
  • vicugna pacos (alpaca)
  • ebola virus
KeywordsVIRAL PROTEIN / EBOV / glycoprotein / nanobody

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