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Structure paper

TitleMolecular recognition of thyroglobulin by sortilin.
Journal, issue, pagesNat Commun, Vol. 17, Year 2026
Publish dateJan 15, 2025 (structure data deposition date)
AuthorsBoniardi, I. / Tanzi, G. / Di Ianni, A. / Graziadei, A. / Nedeljkovic, M. / Stejskalova, C. / Coscia, F.
External linksNat Commun / PubMed:41580413
MethodsEM (single particle)
Resolution3.1 - 3.36 Å
Structure data

PDB-9i0n:
Cryo-EM structure of human sortilin ectodomain
Method: ELECTRON MICROSCOPY / Resolution: 3.1 Å

PDB-9i0o:
Cryo-EM structure of human sortilin ectodomain in complex with a thyroglobulin C-terminal peptide
Method: ELECTRON MICROSCOPY / Resolution: 3.36 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Trafficking / Vacuolar Protein Sorting / VPS10 / Beta propeller / Neurotensin binding receptor 3 / thyroglobulin

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