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TitleHMB-002: a monovalent antibody that elevates circulating VWF and FVIII levels for treatment of von Willebrand disease.
Journal, issue, pagesBlood Adv, Vol. 10, Page 2551-2562, Year 2026
Publish dateApr 4, 2025 (structure data deposition date)
AuthorsHager, M. / Zivkovic, M. / Gandhi, P.S. / Rasmussen, C. / Bonvoisin, C. / Harrison, R.A. / Poulsen, E. / Huskens, D. / Roest, M. / Ferrara, F. ...Hager, M. / Zivkovic, M. / Gandhi, P.S. / Rasmussen, C. / Bonvoisin, C. / Harrison, R.A. / Poulsen, E. / Huskens, D. / Roest, M. / Ferrara, F. / Naretto, A. / Renaud, L. / Olsen, O.H. / Eskesen, N.O. / Holten-Andersen, L. / Malladi, R. / Rea, C.J. / Sorensen, B. / Urbanus, R.T. / Ostergaard, H.
External linksBlood Adv / PubMed:41569789
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-9qrv:
Crystal Structure of an anti-VWF CK Domain Fab in Complex with the C-Terminal CK Domain of Cynomolgus Monkey von Willebrand Factor.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • macaca fascicularis (crab-eating macaque)
  • synthetic construct (others)
KeywordsBLOOD CLOTTING / von Willebrand factor / CK domain / Fab / von Willebrand disease

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