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TitleRO4, a high-affinity humanized antibody against the juxtamembrane region of mesothelin for targeted cancer therapy.
Journal, issue, pagesAntib Ther, Vol. 9, Page 1-12, Year 2026
Publish dateJun 16, 2025 (structure data deposition date)
AuthorsOnda, M. / Liu, X. / Liu, W. / Zhan, J. / Maslanka, C.A. / Xia, D. / Ho, M. / Pastan, I.
External linksAntib Ther / PubMed:41550974
MethodsX-ray diffraction
Resolution1.52 Å
Structure data

PDB-9p4c:
Crystal structure of Mesothelin C-terminal peptide-RO4 Fab complex
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • oryctolagus cuniculus (rabbit)
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / Mesothelin / antibody / IMMUNE SYSTEM

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