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TitleEngineering SIRP alpha conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design.
Journal, issue, pagesBiorxiv, Year 2025
Publish dateAug 28, 2025 (structure data deposition date)
AuthorsStorder, M. / Barelier, S. / Cordier, F. / Yacoub, T. / Ilari, L. / Barral, K. / Mahmoodi, S. / Saez-Ayala, M. / Combes, S. / Betzi, S. ...Storder, M. / Barelier, S. / Cordier, F. / Yacoub, T. / Ilari, L. / Barral, K. / Mahmoodi, S. / Saez-Ayala, M. / Combes, S. / Betzi, S. / Derviaux, C. / Ulliana, A. / Torres, F. / Rubin, J. / Roche, P. / Morelli, X. / Garcin, E.D. / Miller, T.W.
External linksBiorxiv / PubMed:41497624
MethodsX-ray diffraction
Resolution1.5 - 1.83 Å
Structure data

PDB-9sia:
Crystal structure of human Signal Regulatory Protein 2 (SIRP) alpha V2 in complex with L-Tryptophane
Method: X-RAY DIFFRACTION / Resolution: 1.83 Å

PDB-9sic:
Crystal structure of human Signal Regulatory Protein 2 (SIRP) alpha V2 - Q52A mutant
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-9sid:
Crystal structure of human Signal Regulatory Protein 2 (SIRP) alpha V2 - Q52F mutant
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-9t7f:
Crystal structure of human Signal Regulatory Protein 2 (SIRP) alpha V2 in complex with 5-Hydroxy-L-Tryptophan
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-9tf5:
Structure of human wild-type signal regulatory protein alpha V2 variant (SIRPaV2) with zinc
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-TRP:
TRYPTOPHAN

ChemComp-HOH:
WATER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-4PQ:
5-hydroxy-L-tryptophan / medication*YM

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IMMUNOGLOBULIN SUPERFAMILY / SIRP / SIRPA / DON'T EAT ME SIGNAL / IMMUNE CHECKPOINT / TRYPTOPHANE / COMPLEX / CD47 / 5-HYDROX-TRYPTOPHAN / Signal regulatory protein alpha / paired receptor / SIRPalpha / SIRPaV2

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