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TitleStructural basis for diosgenin as an inverse agonist of retinoic acid receptor-related orphan receptor gamma.
Journal, issue, pagesSci Rep, Vol. 16, Page 4765-4765, Year 2026
Publish dateJul 23, 2025 (structure data deposition date)
AuthorsChen, S. / Tian, S. / Liang, J. / Wang, R. / Li, Y.
External linksSci Rep / PubMed:41495387
MethodsX-ray diffraction
Resolution2.18 Å
Structure data

PDB-9vzq:
Crystal structure of RORgamma in complex with novel inverse agonist
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-YUV:
(25R)-14beta,17beta-spirost-5-en-3beta-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / inverse agonist

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