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TitleTargeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy.
Journal, issue, pagesNat. Immunol., Year 2026
Publish dateMay 13, 2025 (structure data deposition date)
AuthorsFang, C. / Esposito, M. / Hars, U. / Byrne, R.T. / Song, B. / Huang, J. / Roichman, A. / Shue, L. / Cheng, X. / Proudfoot, J. ...Fang, C. / Esposito, M. / Hars, U. / Byrne, R.T. / Song, B. / Huang, J. / Roichman, A. / Shue, L. / Cheng, X. / Proudfoot, J. / Zhao, D. / Wei, Y. / Cristea, I.M. / Rabinowitz, J.D. / Kang, Y.
External linksNat. Immunol. / PubMed:41491403
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-9r6n:
Crystal structure of ALDH1A2 in complex with KyA33
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

PDB-1idq:
CRYSTAL STRUCTURE OF NATIVE VANADIUM-CONTAINING CHLOROPEROXIDASE FROM CURVULARIA INAEQUALIS

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Inhibitor

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