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TitleHuman FcRL5 is an Fc receptor that simultaneously engages two IgGs.
Journal, issue, pagesSci Adv, Vol. 12, Issue 1, Page eaeb8865, Year 2026
Publish dateJan 2, 2026
AuthorsShihua Chen / Shuhan Li / Zhiying Zhang / Junyu Xiao /
PubMed AbstractThe Fc receptors play crucial roles in initiating the effector functions of immunoglobulins. FcRL5 is a prominent target in B cell malignancies and has been implicated as a receptor for ...The Fc receptors play crucial roles in initiating the effector functions of immunoglobulins. FcRL5 is a prominent target in B cell malignancies and has been implicated as a receptor for immunoglobulin G (IgG). However, the molecular mechanism remained unclear. Here, we demonstrate that human FcRL5, but not its mouse counterpart, is a bona fide IgG-Fc (Fcγ) receptor that uniquely requires the presence of two Fcγ molecules in close proximity to form a robust interaction. Cryo-electron microscopy reveals that FcRL5 optimally engages two Fcγ molecules positioned at a 60° angle, with its D1-D2 domains binding to the first Fcγ molecule, while its D3 domain arches over the second Fcγ. This distinctive binding capability enables FcRL5 to specifically recognize IgG immune complexes (ICs), with the binding strength correlating with IgG concentration in the ICs. In addition, we demonstrate that FcRL5 can internalize the IgG polymer and IC. These results shed light on FcRL5 function and reveal a unique Fcγ-FcγR binding mode governed by avidity.
External linksSci Adv / PubMed:41477863 / PubMed Central
MethodsEM (single particle)
Resolution3.16 - 3.56 Å
Structure data

63244

9loc

EMDB-63244, PDB-9loc:
Cryo-EM structure of human FcRL5 bound to IgG-Fc
Method: EM (single particle) / Resolution: 3.56 Å

63245

9lod

EMDB-63245, PDB-9lod:
Local structure of human FcRL5 bound to IgG-Fc
Method: EM (single particle) / Resolution: 3.16 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / IgG / FcRL5

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